Dr. Karim Maghni

Karim-Maghni
Associate Professor, Université de Montréal
Sacré Coeur Hospital, Research Centre
Respiratory Divison
Office: (514) 338-2222 ext: 3662
FAX: (514) 338-3123
E-mail: karim.maghni@umontreal.ca
Department web site: http://www.axe-recherche-sante-respiratoire.org
Asthma in the workplace center web site: http://www.asthma-workplace.com/
Dr Maghni’s laboratory web site: http://www.asthma-neuroimmunology.com/

Research Interest

Dr Maghni is an associate professor in the department of Medicine at the Université de Montréal. He is also a member of the “Axe de recherche en Santé Respiratoire” Sacré-Coeur Hospital, Montreal. Dr. Maghni is well recognized for his in vivo and in vitro studies on inflammatory mechanisms in airways, and most recently for his studies on neuroimmune interactions, particularly between tachykinins and immune cells in the pathogenesis of asthma. His recent discovery of a new mechanism in the regulation of immuno-inflammatory reactions involving metachromatic cells and the FcepsilonRI receptor has led to an International Patent Cooperation Treaty (PCT) application registered in 2007, entitled “Compounds and methods of treating disorders associated with activation of metachromatic cells” (WO2007/096782). He is also interested by immuno-inflammatory mechanisms involved in the onset and chronicity of occupational asthma. He has recently extended is field of research to the study of nanoparticles and lung toxicity. He is a member of the Quebecer Community in Nanotoxicology, an initiative of The Research Network in Health and Security in the Workplace of Quebec supported by the FRSQ (Fonds de Recherche en Santé du Québec).

References

  • Bosse, Y., Maghni, K., Hudson, T.J. 1{alpha}, 25-dihydroxy-vitamin D3 stimulation of bronchial smooth muscle cells induces autocrine, contractility and remodeling processes. Physiol Genomics. 29:161-168, 2007
  • Maghni, K., Lemière, C., Ghezzo. H., Yuquan, W., Malo, J-L. Persistent airway inflammation after cessation of exposure to an agent causing occupational asthma. Am. J. Resp. Critical Care Med., 169: 367-372, 2004.
  • Maghni, K., Taha, R., Afif, W., Hamid, Q.A., Martin, J.G. Dichotomy between neurokinin receptors action in modulating the airway allergic responses in an animal model of Th2 cytokine-associated inflammation. Am. J. Resp. Critical Care Med. 162: 1068-1074, 2000.